Microwave-vacuum (MV) drying characteristics of plantation Masson pine (Pinus massoniana) were studied experimentally for various levels of microwave radiation time, initial moisture content (MC), vacuum level and wood thickness. The results show that the process of MV drying for wood can be significantly divided into a short accelerating rate drying period, a long constant rate drying period and falling rate drying period, and the second drying period can extend to levels of mean MC below the fiber saturation point. With the increase of initial MC and microwave radiation time, the drying rate of wood increases significantly. The vacuum level affects the drying rate in a slightly positive way. Within the range of 2 to 6 cm, the effects of sample thickness on the drying rate can be negligible.